Brian J. Popko

Research Summary
Dr. Popko's laboratory has a long-standing interest in the glial cells of the nervous system, particularly in those responsible for the formation of the myelin sheath. These interests range from a basic understanding of the myelination process to disease mechanisms, genetic and acquired, that disrupt this critical component of the nervous system. The genetic mouse models utilized by the Popko lab have been instrumental in expanding knowledge of the myelination process and of demyelinating disorders. Over the past two decades, Dr. Popko's studies have contributed to our understanding of myelin-specific proteins and lipids that play critical roles in myelin formation and maintenance. His lab also has a keen interest in the effect of the inflammatory response on myelinating cells, which is of critical importance to the pathogenesis of immune-mediated demyelinating disorders.
myelin, glial cells, oligodendrocytes, Schwann Cells, mouse models, demyelination, remyelination
  • Pennsylvania State University, State College, PA, Bsc Microbiology and immunology 06/1980
  • University of Miami School of Medicine, Miami, FL, PhD Microbiology and immunology 12/1985
  • California Institute of Technology, Pasadena, CA, Postdoctoral Fellow Molecular Neuroscience 04/1988
Biosciences Graduate Program Association
Awards & Honors
  • 1991 - 1993 Neuroscience Research Fellowship Alfred P. Sloan Foundation
  • 1993 - 1998 Research Career Development Award NIH
  • 1993 - Jordi Folch-Pi Award American Society for Neurochemistry
  • 1998 - Kenan Research and Study Leave University of North Carolina at Chapel Hill
  • 2002 - pres Jack Miller Professorship in Neurological Disorders The University of Chicago
  • 2003 - Grass Traveling Scientist Society for Neuroscience
  • 2004 - pres Member Faculty of 1000
  • 2012 - Paul and Mindy Purcell Translational Medicine Award Myelin Repair Foundation
  • 2017 - pres Editorial Board Member Glia
  1. Dzhashiashvili Y, Monckton CP, Shah HS, Kunjamma RB, Popko B. The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS. Neurobiol Dis. 2019 07; 127:527-544. View in: PubMed

  2. Elbaz B, Popko B. Molecular Control of Oligodendrocyte Development. Trends Neurosci. 2019 04; 42(4):263-277. View in: PubMed

  3. Chen Y, Podojil JR, Kunjamma RB, Jones J, Weiner M, Lin W, Miller SD, Popko B. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019 02 01; 142(2):344-361. View in: PubMed

  4. Brugarolas P, Reich DS, Popko B. Detecting Demyelination by PET: The Lesion as Imaging Target. Mol Imaging. 2018 Jan-Dec; 17:1536012118785471. View in: PubMed

  5. Elbaz B, Aaker JD, Isaac S, Kolarzyk A, Brugarolas P, Eden A, Popko B. Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation. Cell Rep. 2018 05 22; 23(8):2254-2263. View in: PubMed

  6. Chen Y, Popko B. Cholesterol crystals impede nerve repair. Science. 2018 02 09; 359(6376):635-636. View in: PubMed

  7. Brugarolas P, Sánchez-Rodríguez JE, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607. View in: PubMed

  8. McKenzie AT, Moyon S, Wang M, Katsyv I, Song WM, Zhou X, Dammer EB, Duong DM, Aaker J, Zhao Y, Beckmann N, Wang P, Zhu J, Lah JJ, Seyfried NT, Levey AI, Katsel P, Haroutunian V, Schadt EE, Popko B, Casaccia P, Zhang B. Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease. Mol Neurodegener. 2017 11 06; 12(1):82. View in: PubMed

  9. Clayton BL, Huang A, Kunjamma RB, Solanki A, Popko B. The integrated stress response in hypoxia-induced diffuse white matter injury. J Neurosci. 2017 Jul 18. View in: PubMed

  10. Khalyfa A, Qiao Z, Gileles-Hillel A, Khalyfa AA, Akbarpour M, Popko B, Gozal D. Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea. Am J Respir Cell Mol Biol. 2017 10; 57(4):477-486. View in: PubMed

  11. Trzepizur W, Khalyfa A, Qiao Z, Popko B, Gozal D. Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring. Metabolism. 2017 04; 69:188-198. View in: PubMed

  12. Clayton BL, Huang A, Dukala D, Soliven B, Popko B. Neonatal Hypoxia Results in Peripheral Nerve Abnormalities. Am J Pathol. 2017 Feb; 187(2):245-251. View in: PubMed

  13. Aaker JD, Elbaz B, Wu Y, Looney TJ, Zhang L, Lahn BT, Popko B. Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice. ASN Neuro. 2016 Oct; 8(5). View in: PubMed

  14. De Rossi P, Buggia-Prévot V, Clayton BL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, Thinakaran G. Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol Neurodegener. 2016 08 03; 11(1):59. View in: PubMed

  15. Elbaz B, Traka M, Kunjamma RB, Dukala D, Brosius Lutz A, Anton ES, Barres BA, Soliven B, Popko B. Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS. Development. 2016 07 01; 143(13):2356-66. View in: PubMed

  16. Clayton BLL, Popko B. Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia. Brain Res. 2016 10 01; 1648(Pt B):594-602. View in: PubMed

  17. Berthoud VM, Minogue PJ, Snabb JI, Dzhashiashvili Y, Novak LA, Zoltoski RK, Popko B, Beyer EC. Connexin23 deletion does not affect lens transparency. Exp Eye Res. 2016 05; 146:283-8. View in: PubMed

  18. Way SW, Popko B. Harnessing the integrated stress response for the treatment of multiple sclerosis. Lancet Neurol. 2016 Apr; 15(4):434-43. View in: PubMed

  19. Traka M, Podojil JR, McCarthy DP, Miller SD, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016 Jan; 19(1):65-74. View in: PubMed

  20. Hussien Y, Podojil JR, Robinson AP, Lee AS, Miller SD, Popko B. ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis. J Neurosci. 2015 Dec 02; 35(48):15921-33. View in: PubMed

  21. Way SW, Podojil JR, Clayton BL, Zaremba A, Collins TL, Kunjamma RB, Robinson AP, Brugarolas P, Miller RH, Miller SD, Popko B. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun. 2015 Mar 13; 6:6532. View in: PubMed

  22. Brugarolas P, Popko B. Remyelination therapy goes to trial for multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2014 Aug; 1(2):e26. View in: PubMed

  23. Wang L, Popko B, Tixier E, Roos RP. Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol Dis. 2014 Nov; 71:317-24. View in: PubMed

  24. Hussien Y, Cavener DR, Popko B. Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination. Glia. 2014 May; 62(5):680-91. View in: PubMed

  25. Wang L, Popko B, Roos RP. An enhanced integrated stress response ameliorates mutant SOD1-induced ALS. Hum Mol Genet. 2014 May 15; 23(10):2629-38. View in: PubMed

  26. Traka M, Millen KJ, Collins D, Elbaz B, Kidd GJ, Gomez CM, Popko B. WDR81 is necessary for purkinje and photoreceptor cell survival. J Neurosci. 2013 Apr 17; 33(16):6834-44. View in: PubMed

  27. Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci. 2013 Apr 03; 33(14):5980-91. View in: PubMed

  28. Popko B. Downregulating DR6 to drive remyelination. Nat Med. 2011 Jul 07; 17(7):779-80. View in: PubMed

  29. Bommiasamy H, Popko B. Animal models in the study of the unfolded protein response. Methods Enzymol. 2011; 491:91-109. View in: PubMed

  30. Wang L, Popko B, Roos RP. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum Mol Genet. 2011 Mar 01; 20(5):1008-15. View in: PubMed

  31. Traka M, Arasi K, Avila RL, Podojil JR, Christakos A, Miller SD, Soliven B, Popko B. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. Brain. 2010 Oct; 133(10):3017-29. View in: PubMed

  32. Popko B. Myelin maintenance: axonal support required. Nat Neurosci. 2010 Mar; 13(3):275-7. View in: PubMed

  33. Howng SY, Avila RL, Emery B, Traka M, Lin W, Watkins T, Cook S, Bronson R, Davisson M, Barres BA, Popko B. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev. 2010 Feb 01; 24(3):301-11. View in: PubMed

  34. Howng SY, Douglas DS, Popko B. A G-coupled receptor protein critical for peripheral nerve myelination. J Mol Cell Biol. 2010 Jun; 2(3):105-6. View in: PubMed

  35. Douglas DS, Moran JL, Bermingham JR, Chen XJ, Brindley DN, Soliven B, Beier DR, Popko B. Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci. 2009 Sep 30; 29(39):12089-100. View in: PubMed

  36. Saadat L, Dupree JL, Kilkus J, Han X, Traka M, Proia RL, Dawson G, Popko B. Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia. 2010 Mar; 58(4):391-8. View in: PubMed

  37. Lin W, Popko B. Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci. 2009 Apr; 12(4):379-85. View in: PubMed

  38. Traka M, Wollmann RL, Cerda SR, Dugas J, Barres BA, Popko B. Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci. 2008 Nov 05; 28(45):11537-49. View in: PubMed

  39. Hitoshi Y, Harris BT, Liu H, Popko B, Israel MA. Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. Cancer Res. 2008 Oct 15; 68(20):8507-15. View in: PubMed

  40. Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Am J Pathol. 2008 Nov; 173(5):1508-17. View in: PubMed

  41. Popko B. Epigenetic control of myelin repair. Nat Neurosci. 2008 Sep; 11(9):987-8. View in: PubMed

  42. Dupree JL, Mason JL, Marcus JR, Stull M, Levinson R, Matsushima GK, Popko B. Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biol. 2004 Aug; 1(3):179-92. View in: PubMed

  43. Douglas DS, Popko B. Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy. Neurochem Res. 2009 Jan; 34(1):124-37. View in: PubMed

  44. Baida G, Popko B, Wollmann RL, Stavrou S, Lin W, Tretiakova M, Krausz TN, Roos RP. A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination. J Virol. 2008 Jun; 82(12):5879-86. View in: PubMed

  45. Chen XJ, Levedakou EN, Millen KJ, Wollmann RL, Soliven B, Popko B. Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. J Neurosci. 2007 Dec 26; 27(52):14515-24. View in: PubMed

  46. Ghashghaei HT, Weimer JM, Schmid RS, Yokota Y, McCarthy KD, Popko B, Anton ES. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes Dev. 2007 Dec 15; 21(24):3258-71. View in: PubMed

  47. Balabanov R, Strand K, Goswami R, McMahon E, Begolka W, Miller SD, Popko B. Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis. J Neurosci. 2007 Feb 21; 27(8):2013-24. View in: PubMed

  48. Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest. 2007 Feb; 117(2):448-56. View in: PubMed

  49. Traka M, Seburn KL, Popko B. Nmf11 is a novel ENU-induced mutation in the mouse glycine receptor alpha 1 subunit. Mamm Genome. 2006 Sep; 17(9):950-5. View in: PubMed

  50. Levedakou EN, Popko B. Rewiring enervated: thinking LARGEr than myodystrophy. J Neurosci Res. 2006 Aug 01; 84(2):237-43. View in: PubMed

  51. Balabanov R, Strand K, Kemper A, Lee JY, Popko B. Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-gamma. J Neurosci. 2006 May 10; 26(19):5143-52. View in: PubMed

  52. Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B. Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain. 2006 May; 129(Pt 5):1306-18. View in: PubMed

  53. Lin W, Harding HP, Ron D, Popko B. Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol. 2005 May 23; 169(4):603-12. View in: PubMed

  54. Levedakou EN, Chen XJ, Soliven B, Popko B. Disruption of the mouse Large gene in the enr and myd mutants results in nerve, muscle, and neuromuscular junction defects. Mol Cell Neurosci. 2005 Apr; 28(4):757-69. View in: PubMed

  55. Balabanov R, Popko B. Myelin repair: developmental myelination redux? Nat Neurosci. 2005 Mar; 8(3):262-4. View in: PubMed

  56. Wang J, Lin W, Popko B, Campbell IL. Inducible production of interferon-gamma in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway. Mol Cell Neurosci. 2004 Dec; 27(4):489-96. View in: PubMed

  57. Lin W, Kemper A, McCarthy KD, Pytel P, Wang JP, Campbell IL, Utset MF, Popko B. Interferon-gamma induced medulloblastoma in the developing cerebellum. J Neurosci. 2004 Nov 10; 24(45):10074-83. View in: PubMed

  58. Ye P, Popken GJ, Kemper A, McCarthy K, Popko B, D'Ercole AJ. Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression. J Neurosci Res. 2004 Nov 15; 78(4):472-84. View in: PubMed

  59. Popko B. Notch signaling: a rheostat regulating oligodendrocyte differentiation? Dev Cell. 2003 Nov; 5(5):668-9. View in: PubMed

  60. Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC. Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. EMBO J. 2003 Nov 03; 22(21):5666-78. View in: PubMed

  61. Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 Mar; 11(3):619-33. View in: PubMed

  62. Popko B. Myelin: not just a conduit for conduction. Nat Genet. 2003 Mar; 33(3):327-8. View in: PubMed

  63. Rosenbluth J, Dupree JL, Popko B. Nodal sodium channel domain integrity depends on the conformation of the paranodal junction, not on the presence of transverse bands. Glia. 2003 Feb; 41(3):318-25. View in: PubMed

  64. Doerflinger NH, Macklin WB, Popko B. Inducible site-specific recombination in myelinating cells. Genesis. 2003 Jan; 35(1):63-72. View in: PubMed

  65. Marcus J, Popko B. Galactolipids are molecular determinants of myelin development and axo-glial organization. Biochim Biophys Acta. 2002 Dec 19; 1573(3):406-13. View in: PubMed

  66. Ishibashi T, Dupree JL, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Suzuki K, Nishino H, Baba H. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci. 2002 Aug 01; 22(15):6507-14. View in: PubMed

  67. Traka M, Dupree JL, Popko B, Karagogeos D. The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers. J Neurosci. 2002 Apr 15; 22(8):3016-24. View in: PubMed

  68. Popko B, Pearl DK, Walker DM, Comas TC, Baerwald KD, Burger PC, Scheithauer BW, Yates AJ. Molecular markers that identify human astrocytomas and oligodendrogliomas. J Neuropathol Exp Neurol. 2002 Apr; 61(4):329-38. View in: PubMed

  69. Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y, Taniguchi N. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4227-32. View in: PubMed

  70. Marcus J, Dupree JL, Popko B. Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions. J Cell Biol. 2002 Feb 04; 156(3):567-77. View in: PubMed

  71. Gao X, Gillig TA, Ye P, D'Ercole AJ, Matsushima GK, Popko B. Interferon-gamma protects against cuprizone-induced demyelination. Mol Cell Neurosci. 2000 Oct; 16(4):338-49. View in: PubMed

  72. Marcus J, Dupree JL, Popko B. Effects of galactolipid elimination on oligodendrocyte development and myelination. Glia. 2000 Jun; 30(4):319-28. View in: PubMed

  73. Dupree JL, Popko B. Genetic dissection of myelin galactolipid function. J Neurocytol. 1999 Apr-May; 28(4-5):271-9. View in: PubMed

  74. Ezoe T, Vanier MT, Oya Y, Popko B, Tohyama J, Matsuda J, Suzuki K, Suzuki K. Twitcher mice with only a single active galactosylceramide synthase gene exhibit clearly detectable but therapeutically minor phenotypic improvements. J Neurosci Res. 2000 Jan 15; 59(2):179-87. View in: PubMed

  75. Ezoe T, Vanier MT, Oya Y, Popko B, Tohyama J, Matsuda J, Suzuki K, Suzuki K. Biochemistry and neuropathology of mice doubly deficient in synthesis and degradation of galactosylceramide. J Neurosci Res. 2000 Jan 15; 59(2):170-8. View in: PubMed

  76. Baerwald KD, Corbin JG, Popko B. Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities. J Neurosci Res. 2000 Jan 15; 59(2):160-9. View in: PubMed

  77. Popko B, Dupree JL, Coetzee T, Suzuki K, Suzuki K. Genetic analysis of myelin galactolipid function. Adv Exp Med Biol. 1999; 468:237-44. View in: PubMed

  78. Popko B. Myelin galactolipids: mediators of axon-glial interactions? Glia. 2000 Jan 15; 29(2):149-53. View in: PubMed

  79. Dupree JL, Girault JA, Popko B. Axo-glial interactions regulate the localization of axonal paranodal proteins. J Cell Biol. 1999 Dec 13; 147(6):1145-52. View in: PubMed

  80. Gao X, Kemper A, Popko B. Advanced transgenic and gene-targeting approaches. Neurochem Res. 1999 Sep; 24(9):1181-8. View in: PubMed

  81. Dupree JL, Coetzee T, Suzuki K, Popko B. Myelin abnormalities in mice deficient in galactocerebroside and sulfatide. J Neurocytol. 1998 Sep; 27(9):649-59. View in: PubMed

  82. Coetzee T, Suzuki K, Nave KA, Popko B. Myelination in the absence of galactolipids and proteolipid proteins. Mol Cell Neurosci. 1999 Jul; 14(1):41-51. View in: PubMed

  83. Suzuki K, Vanier MT, Coetzee T, Popko B. Drastically abnormal gluco- and galactosylceramide composition does not affect ganglioside metabolism in the brain of mice deficient in galactosylceramide synthase. Neurochem Res. 1999 Apr; 24(4):471-4. View in: PubMed

  84. Popko B, Baerwald KD. Oligodendroglial response to the immune cytokine interferon gamma. Neurochem Res. 1999 Feb; 24(2):331-8. View in: PubMed

  85. Coetzee T, Dupree JL, Popko B. Demyelination and altered expression of myelin-associated glycoprotein isoforms in the central nervous system of galactolipid-deficient mice. J Neurosci Res. 1998 Dec 01; 54(5):613-22. View in: PubMed

  86. Dupree JL, Suzuki K, Popko B. Galactolipids in the formation and function of the myelin sheath. Microsc Res Tech. 1998 Jun 01; 41(5):431-40. View in: PubMed

  87. Baerwald KD, Popko B. Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma. J Neurosci Res. 1998 Apr 15; 52(2):230-9. View in: PubMed

  88. Roses AD, Gilbert J, Xu PT, Sullivan P, Popko B, Burkhart DS, Christian-Rothrock T, Saunders AM, Maeda N, Schmechel DE. Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S53-8. View in: PubMed

  89. Coetzee T, Suzuki K, Popko B. New perspectives on the function of myelin galactolipids. Trends Neurosci. 1998 Mar; 21(3):126-30. View in: PubMed

  90. Taniike M, Marcus JR, Nishigaki T, Fujita N, Popko B, Suzuki K, Suzuki K. Suppressed UDP-galactose: ceramide galactosyltransferase and myelin protein mRNA in twitcher mouse brain. J Neurosci Res. 1998 Feb 15; 51(4):536-40. View in: PubMed

  91. Fujita N, Kemper A, Dupree J, Nakayasu H, Bartsch U, Schachner M, Maeda N, Suzuki K, Popko B. The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J Neurosci. 1998 Mar 15; 18(6):1970-8. View in: PubMed

  92. Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. J Neurosci. 1998 Mar 01; 18(5):1642-9. View in: PubMed

  93. Popko B, Corbin JG, Baerwald KD, Dupree J, Garcia AM. The effects of interferon-gamma on the central nervous system. Mol Neurobiol. 1997 Feb-Apr; 14(1-2):19-35. View in: PubMed

  94. Taniike M, Marcus JR, Popko B, Suzuki K. Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS. J Neurosci Res. 1997 Mar 01; 47(5):539-46. View in: PubMed

  95. Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis. 1996; 3(3):229-45. View in: PubMed

  96. Corbin JG, Kelly D, Rath EM, Baerwald KD, Suzuki K, Popko B. Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Mol Cell Neurosci. 1996 May; 7(5):354-70. View in: PubMed

  97. Fujita N, Suzuki K, Vanier MT, Popko B, Maeda N, Klein A, Henseler M, Sandhoff K, Nakayasu H, Suzuki K. Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Hum Mol Genet. 1996 Jun; 5(6):711-25. View in: PubMed

  98. Coetzee T, Fujita N, Dupree J, Shi R, Blight A, Suzuki K, Suzuki K, Popko B. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell. 1996 Jul 26; 86(2):209-19. View in: PubMed

  99. Coetzee T, Li X, Fujita N, Marcus J, Suzuki K, Francke U, Popko B. Molecular cloning, chromosomal mapping, and characterization of the mouse UDP-galactose:ceramide galactosyltransferase gene. Genomics. 1996 Jul 01; 35(1):215-22. View in: PubMed

  100. Popko B, Goodrum JF, Bouldin TW, Zhang SH, Maeda N. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J Neurochem. 1993 Mar; 60(3):1155-8. View in: PubMed

  101. Bennett E, Stenvers KL, Lund PK, Popko B. Cloning and characterization of a cDNA encoding a novel fatty acid binding protein from rat brain. J Neurochem. 1994 Nov; 63(5):1616-24. View in: PubMed

  102. Goodrum JF, Bouldin TW, Zhang SH, Maeda N, Popko B. Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem. 1995 Jan; 64(1):408-16. View in: PubMed

  103. Li Y, Atashi J, Hayes C, Reap E, Hunt S, Popko B. Morphological and molecular response of the MOCH-1 oligodendrocyte cell line to serum and interferon-gamma: possible implications for demyelinating disorders. J Neurosci Res. 1995 Feb 01; 40(2):189-98. View in: PubMed

  104. Stahl N, Jurevics H, Morell P, Suzuki K, Popko B. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase. J Neurosci Res. 1994 Jun 01; 38(2):234-42. View in: PubMed

  105. Kelly D, Chancellor K, Milatovich A, Francke U, Suzuki K, Popko B. Autosomal recessive neuromuscular disorder in a transgenic line of mice. J Neurosci. 1994 Jan; 14(1):198-207. View in: PubMed

  106. Rath EM, Kelly D, Bouldin TW, Popko B. Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect. J Neurosci. 1995 Nov; 15(11):7226-37. View in: PubMed

  107. Pauley RJ, Parks WP, Popko BJ. Expression and demethylation of germinally-transmitted BALB/c mouse mammary tumor virus DNA in Abelson MuLV B-lymphoid cell lines. Virus Res. 1984; 1(5):381-400. View in: PubMed

  108. Popko BJ, Pauley RJ. Organization and expression of mouse mammary tumor virus sequences in normal and neoplastic C3Hf/HeSed mouse tissues. J Virol. 1984 Nov; 52(2):328-35. View in: PubMed

  109. Popko BJ, Pauley RJ. Mammary tumorigenesis in C3Hf/Ki mice: examination of germinal mouse mammary tumor viruses and the int-1 and int-2 putative proto-oncogenes. Virus Res. 1985 Apr; 2(3):231-43. View in: PubMed

  110. Popko B, Puckett C, Hood L. A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts. Neuron. 1988 May; 1(3):221-5. View in: PubMed

  111. Popko B, Puckett C, Lai E, Shine HD, Readhead C, Takahashi N, Hunt SW, Sidman RL, Hood L. Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. Cell. 1987 Feb 27; 48(4):713-21. View in: PubMed

  112. Readhead C, Popko B, Takahashi N, Shine HD, Saavedra RA, Sidman RL, Hood L. Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell. 1987 Feb 27; 48(4):703-12. View in: PubMed

  113. Popko B. Molecular characterization of the murine mutation myelin deficient. Epilepsy Res Suppl. 1991; 4:275-82. View in: PubMed

  114. You KH, Hsieh CL, Hayes C, Stahl N, Francke U, Popko B. DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles. Genomics. 1991 Apr; 9(4):751-7. View in: PubMed

  115. Toews AD, Lee SY, Popko B, Morell P. Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression. J Neurosci Res. 1990 Aug; 26(4):501-7. View in: PubMed

  116. Stahl N, Harry J, Popko B. Quantitative analysis of myelin protein gene expression during development in the rat sciatic nerve. Brain Res Mol Brain Res. 1990 Aug; 8(3):209-12. View in: PubMed

  117. Fremeau RT, Popko B. In situ analysis of myelin basic protein gene expression in myelin-deficient oligodendrocytes: antisense hnRNA and readthrough transcription. EMBO J. 1990 Nov; 9(11):3533-8. View in: PubMed

  118. Shine HD, Readhead C, Popko B, Hood L, Sidman RL. Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system. Prog Clin Biol Res. 1990; 336:81-92. View in: PubMed

  119. Boylan KB, Ayres TM, Popko B, Takahashi N, Hood LE, Prusiner SB. Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism. Genomics. 1990 Jan; 6(1):16-22. View in: PubMed

  120. Hayes C, Kelly D, Murayama S, Komiyama A, Suzuki K, Popko B. Expression of the neu oncogene under the transcriptional control of the myelin basic protein gene in transgenic mice: generation of transformed glial cells. J Neurosci Res. 1992 Jan; 31(1):175-87. View in: PubMed

  121. Francke U, Hsieh CL, Kelly D, Lai E, Popko B. Induced reciprocal translocation in transgenic mice near sites of transgene integration. Mamm Genome. 1992; 3(4):209-16. View in: PubMed

  122. Shine HD, Readhead C, Popko B, Hood L, Sidman RL. Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis. J Neurochem. 1992 Jan; 58(1):342-9. View in: PubMed

  123. Skinner CA, Kelly D, Kao LR, Nayfeh SN, Popko B, Chae CB. Thyroid-specific and hormone-dependent expression of rat thyroglobulin promoter fused with bacterial chloramphenicol acetyltransferase gene in transgenic mice. Mol Cell Endocrinol. 1992 Dec; 90(1):33-8. View in: PubMed