Martin Kreitman

Biosciences Graduate Program Association
Publications
  1. MacQueen A, Tian D, Chang W, Holub E, Kreitman M, Bergelson J. Population Genetics of the Highly Polymorphic RPP8 Gene Family. Genes (Basel). 2019 09 08; 10(9). View in: PubMed

  2. Simmons GM, Kreitman ME, Quattlebaum WF, Miyashita N. MOLECULAR ANALYSIS OF THE ALLELES OF ALCOHOL DEHYDROGENASE ALONG A CLINE IN DROSOPHILA MELANOGASTER. I. MAINE, NORTH CAROLINA, AND FLORIDA. Evolution. 1989 Mar; 43(2):393-409. View in: PubMed

  3. Coyne JA, Kreitman M. EVOLUTIONARY GENETICS OF TWO SIBLING SPECIES, DROSOPHILA SIMULANS AND D. SECHELLIA. Evolution. 1986 Jul; 40(4):673-691. View in: PubMed

  4. Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. View in: PubMed

  5. Jiang P, Ludwig MZ, Kreitman M, Reinitz J. Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster. Dev Biol. 2015 Sep 01; 405(1):173-81. View in: PubMed

  6. Jha AR, Miles CM, Lippert NR, Brown CD, White KP, Kreitman M. Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster. Mol Biol Evol. 2015 Oct; 32(10):2616-32. View in: PubMed

  7. Palsson A, Wesolowska N, Reynisdóttir S, Ludwig MZ, Kreitman M. Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer. PLoS One. 2014; 9(5):e91924. View in: PubMed

  8. Martinez C, Rest JS, Kim AR, Ludwig M, Kreitman M, White K, Reinitz J. Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change. Mol Biol Evol. 2014 Apr; 31(4):903-16. View in: PubMed

  9. Cheung D, Miles C, Kreitman M, Ma J. Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos. Development. 2014 Jan; 141(1):124-35. View in: PubMed

  10. He BZ, Ludwig MZ, Dickerson DA, Barse L, Arun B, Vilhjálmsson BJ, Jiang P, Park SY, Tamarina NA, Selleck SB, Wittkopp PJ, Bell GI, Kreitman M. Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):557-67. View in: PubMed

  11. Park SY, Ludwig MZ, Tamarina NA, He BZ, Carl SH, Dickerson DA, Barse L, Arun B, Williams CL, Miles CM, Philipson LH, Steiner DF, Bell GI, Kreitman M. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):539-55. View in: PubMed

  12. Sex-specific pattern formation during early Drosophila development. Genetics. 2013 May; 194(1):163-73. View in: PubMed

  13. Finefield JM, Sherman DH, Kreitman M, Williams RM. Enantiomeric natural products: occurrence and biogenesis. Angew Chem Int Ed Engl. 2012 May 14; 51(20):4802-36. View in: PubMed

  14. Ludwig MZ. Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness. PLoS Genet. 2011 Nov; 7(11):e1002364. View in: PubMed

  15. Cheung D, Miles C, Kreitman M, Ma J. Scaling of the Bicoid morphogen gradient by a volume-dependent production rate. Development. 2011 Jul; 138(13):2741-9. View in: PubMed

  16. He BZ, Holloway AK, Maerkl SJ, Kreitman M. Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules. PLoS Genet. 2011 Apr; 7(4):e1002053. View in: PubMed

  17. Ballard JW, Kreitman M. Is mitochondrial DNA a strictly neutral marker? Trends Ecol Evol. 1995 Dec; 10(12):485-8. View in: PubMed

  18. Lott SE, Ludwig MZ, Kreitman M. Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia. Evolution. 2011 May; 65(5):1388-99. View in: PubMed

  19. Miles CM, Lott SE, Hendriks CL, Ludwig MZ. Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster. Evolution. 2011 Jan; 65(1):33-42. View in: PubMed

  20. Di Giulio M, Kreitman M. Research on the origin of life. Introduction. J Mol Evol. 2009 Nov; 69(5):405. View in: PubMed

  21. Chen JQ, Wu Y, Yang H, Bergelson J, Kreitman M, Tian D. Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria. Mol Biol Evol. 2009 Jul; 26(7):1523-31. View in: PubMed

  22. Tian D, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J, Chen JQ. Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes. Nature. 2008 Sep 04; 455(7209):105-8. View in: PubMed

  23. Bakker EG, Traw MB, Toomajian C, Kreitman M, Bergelson J. Low levels of polymorphism in genes that control the activation of defense response in Arabidopsis thaliana. Genetics. 2008 Apr; 178(4):2031-43. View in: PubMed

  24. Araki H, Innan H, Kreitman M, Bergelson J. Molecular evolution of pathogenicity-island genes in Pseudomonas viridiflava. Genetics. 2007 Oct; 177(2):1031-41. View in: PubMed

  25. Lott SE, Kreitman M, Palsson A, Alekseeva E, Ludwig MZ. Canalization of segmentation and its evolution in Drosophila. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10926-31. View in: PubMed

  26. Bakker EG, Toomajian C, Kreitman M, Bergelson J. A genome-wide survey of R gene polymorphisms in Arabidopsis. Plant Cell. 2006 Aug; 18(8):1803-18. View in: PubMed

  27. Bakker EG, Stahl EA, Toomajian C, Nordborg M, Kreitman M, Bergelson J. Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range. Mol Ecol. 2006 Apr; 15(5):1405-18. View in: PubMed

  28. Araki H, Tian D, Goss EM, Jakob K, Halldorsdottir SS, Kreitman M, Bergelson J. Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5887-92. View in: PubMed

  29. Nordborg M, Hu TT, Ishino Y, Jhaveri J, Toomajian C, Zheng H, Bakker E, Calabrese P, Gladstone J, Goyal R, Jakobsson M, Kim S, Morozov Y, Padhukasahasram B, Plagnol V, Rosenberg NA, Shah C, Wall JD, Wang J, Zhao K, Kalbfleisch T, Schulz V, Kreitman M, Bergelson J. The pattern of polymorphism in Arabidopsis thaliana. PLoS Biol. 2005 Jul; 3(7):e196. View in: PubMed

  30. Ludwig MZ, Palsson A, Alekseeva E, Bergman CM, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005 Apr; 3(4):e93. View in: PubMed

  31. Qin H, Wu WB, Comeron JM, Kreitman M, Li WH. Intragenic spatial patterns of codon usage bias in prokaryotic and eukaryotic genomes. Genetics. 2004 Dec; 168(4):2245-60. View in: PubMed

  32. Goss EM, Kreitman M, Bergelson J. Genetic diversity, recombination and cryptic clades in Pseudomonas viridiflava infecting natural populations of Arabidopsis thaliana. Genetics. 2005 Jan; 169(1):21-35. View in: PubMed

  33. Kreitman M, Di Rienzo A. Balancing claims for balancing selection. Trends Genet. 2004 Jul; 20(7):300-4. View in: PubMed

  34. Johnson AN, Bergman CM, Kreitman M, Newfeld SJ. Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells. Dev Biol. 2003 Oct 01; 262(1):137-51. View in: PubMed

  35. Toomajian C, Ajioka RS, Jorde LB, Kushner JP, Kreitman M. A method for detecting recent selection in the human genome from allele age estimates. Genetics. 2003 Sep; 165(1):287-97. View in: PubMed

  36. Tian D, Traw MB, Chen JQ, Kreitman M, Bergelson J. Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana. Nature. 2003 May 01; 423(6935):74-7. View in: PubMed

  37. Mauricio R, Stahl EA, Korves T, Tian D, Kreitman M, Bergelson J. Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana. Genetics. 2003 Feb; 163(2):735-46. View in: PubMed

  38. Comeron JM, Kreitman M, De La Vega FM. On the power to detect SNP/phenotype association in candidate quantitative trait loci genomic regions: a simulation study. Pac Symp Biocomput. 2003; 478-89. View in: PubMed

  39. Jakob K, Goss EM, Araki H, Van T, Kreitman M, Bergelson J. Pseudomonas viridiflava and P. syringae--natural pathogens of Arabidopsis thaliana. Mol Plant Microbe Interact. 2002 Dec; 15(12):1195-203. View in: PubMed

  40. Toomajian C, Kreitman M. Sequence variation and haplotype structure at the human HFE locus. Genetics. 2002 Aug; 161(4):1609-23. View in: PubMed

  41. Tian D, Araki H, Stahl E, Bergelson J, Kreitman M. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11525-30. View in: PubMed

  42. Brandt A, Scharf M, Pedra JH, Holmes G, Dean A, Kreitman M, Pittendrigh BR. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Insect Mol Biol. 2002 Aug; 11(4):337-41. View in: PubMed

  43. Comeron JM, Kreitman M. Population, evolutionary and genomic consequences of interference selection. Genetics. 2002 May; 161(1):389-410. View in: PubMed

  44. Jensen MA, Charlesworth B, Kreitman M. Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans. Genetics. 2002 Feb; 160(2):493-507. View in: PubMed

  45. Bernardi G, Gojobori T, Kreitman M. Zuckerkandl Prize. J Mol Evol. 2002 Feb; 54(2):143. View in: PubMed

  46. Nordborg M, Borevitz JO, Bergelson J, Berry CC, Chory J, Hagenblad J, Kreitman M, Maloof JN, Noyes T, Oefner PJ, Stahl EA, Weigel D. The extent of linkage disequilibrium in Arabidopsis thaliana. Nat Genet. 2002 Feb; 30(2):190-3. View in: PubMed

  47. Kreitman M. Methods to detect selection in populations with applications to the human. Annu Rev Genomics Hum Genet. 2000; 1:539-59. View in: PubMed

  48. Bergman CM, Kreitman M. Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences. Genome Res. 2001 Aug; 11(8):1335-45. View in: PubMed

  49. Bergelson J, Kreitman M, Stahl EA, Tian D. Evolutionary dynamics of plant R-genes. Science. 2001 Jun 22; 292(5525):2281-5. View in: PubMed

  50. Kliman RM, Andolfatto P, Coyne JA, Depaulis F, Kreitman M, Berry AJ, McCarter J, Wakeley J, Hey J. The population genetics of the origin and divergence of the Drosophila simulans complex species. Genetics. 2000 Dec; 156(4):1913-31. View in: PubMed

  51. Comeron JM, Kreitman M. The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces. Genetics. 2000 Nov; 156(3):1175-90. View in: PubMed

  52. Brosius J, Kreitman M. Eugenics-evolutionary nonsense? Nat Genet. 2000 Jul; 25(3):253. View in: PubMed

  53. Andolfatto P, Kreitman M. Molecular variation at the In(2L)t proximal breakpoint site in natural populations of Drosophila melanogaster and D. simulans. Genetics. 2000 Apr; 154(4):1681-91. View in: PubMed

  54. Ludwig MZ, Bergman C, Patel NH, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000 Feb 03; 403(6769):564-7. View in: PubMed

  55. Kreitman M, Comeron JM. Coding sequence evolution. Curr Opin Genet Dev. 1999 Dec; 9(6):637-41. View in: PubMed

  56. Andolfatto P, Wall JD, Kreitman M. Unusual haplotype structure at the proximal breakpoint of In(2L)t in a natural population of Drosophila melanogaster. Genetics. 1999 Nov; 153(3):1297-311. View in: PubMed

  57. Stahl EA, Dwyer G, Mauricio R, Kreitman M, Bergelson J. Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis. Nature. 1999 Aug 12; 400(6745):667-71. View in: PubMed

  58. Antezana MA, Kreitman M. The nonrandom location of synonymous codons suggests that reading frame-independent forces have patterned codon preferences. J Mol Evol. 1999 Jul; 49(1):36-43. View in: PubMed

  59. Andreev D, Kreitman M, Phillips TW, Beeman RW, ffrench-Constant RH. Multiple origins of cyclodiene insecticide resistance in Tribolium castaneum (Coleoptera: Tenebrionidae). J Mol Evol. 1999 May; 48(5):615-24. View in: PubMed

  60. Liu F, Charlesworth D, Kreitman M. The effect of mating system differences on nucleotide diversity at the phosphoglucose isomerase locus in the plant genus Leavenworthia. Genetics. 1999 Jan; 151(1):343-57. View in: PubMed

  61. Comeron JM, Kreitman M, Aguadé M. Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila. Genetics. 1999 Jan; 151(1):239-49. View in: PubMed

  62. Comeron JM, Kreitman M. The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints? Genetics. 1998 Oct; 150(2):767-75. View in: PubMed

  63. Zeng LW, Comeron JM, Chen B, Kreitman M. The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila. Genetica. 1998; 102-103(1-6):369-82. View in: PubMed

  64. Hasson E, Wang IN, Zeng LW, Kreitman M, Eanes WF. Nucleotide variation in the triosephosphate isomerase (Tpi) locus of Drosophila melanogaster and Drosophila simulans. Mol Biol Evol. 1998 Jun; 15(6):756-69. View in: PubMed

  65. Bergelson J, Stahl E, Dudek S, Kreitman M. Genetic variation within and among populations of Arabidopsis thaliana. Genetics. 1998 Mar; 148(3):1311-23. View in: PubMed

  66. Ludwig MZ, Patel NH, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998 Mar; 125(5):949-58. View in: PubMed

  67. Ballard JW, Hatzidakis J, Karr TL, Kreitman M. Reduced variation in Drosophila simulans mitochondrial DNA. Genetics. 1996 Dec; 144(4):1519-28. View in: PubMed

  68. Wayne ML, Kreitman M. Reduced variation at concertina, a heterochromatic locus in Drosophila. Genet Res. 1996 Oct; 68(2):101-8. View in: PubMed

  69. Zeng LW, Kreitman M. Simple strategy for sequencing cDNA clones. Biotechniques. 1996 Sep; 21(3):446-52. View in: PubMed

  70. Kreitman M. The neutral theory is dead. Long live the neutral theory. Bioessays. 1996 Aug; 18(8):678-83; discussion 683. View in: PubMed

  71. Wayne ML, Contamine D, Kreitman M. Molecular population genetics of ref(2)P, a locus which confers viral resistance in Drosophila. Mol Biol Evol. 1996 Jan; 13(1):191-9. View in: PubMed

  72. Ludwig MZ, Kreitman M. Evolutionary dynamics of the enhancer region of even-skipped in Drosophila. Mol Biol Evol. 1995 Nov; 12(6):1002-11. View in: PubMed

  73. Landweber LF, Kreitman M. Producing single-stranded DNA in polymerase chain reaction for direct genomic sequencing. Methods Enzymol. 1993; 218:17-26. View in: PubMed

  74. Taylor MF, Heckel DG, Brown TM, Kreitman ME, Black B. Linkage of pyrethroid insecticide resistance to a sodium channel locus in the tobacco budworm. Insect Biochem Mol Biol. 1993 Oct; 23(7):763-75. View in: PubMed

  75. Taylor MF, McKechnie SW, Pierce N, Kreitman M. The lepidopteran mitochondrial control region: structure and evolution. Mol Biol Evol. 1993 Nov; 10(6):1259-72. View in: PubMed

  76. Berry A, Kreitman M. Molecular analysis of an allozyme cline: alcohol dehydrogenase in Drosophila melanogaster on the east coast of North America. Genetics. 1993 Jul; 134(3):869-93. View in: PubMed

  77. Williams WV, Callegari P, Freundlich B, Keenan G, Eldridge D, Shin H, Kreitman M, McCallus D, Weiner DB. Molecular diagnosis of Borrelia burgdorferi infection (Lyme disease). DNA Cell Biol. 1994 Apr; 13(4):447. View in: PubMed

  78. Kreitman M, Wayne ML. Organization of genetic variation at the molecular level: lessons from Drosophila. EXS. 1994; 69:157-83. View in: PubMed

  79. Ballard JW, Kreitman M. Unraveling selection in the mitochondrial genome of Drosophila. Genetics. 1994 Nov; 138(3):757-72. View in: PubMed

  80. Taylor MF, Shen Y, Kreitman ME. A population genetic test of selection at the molecular level. Science. 1995 Dec 01; 270(5241):1497-9. View in: PubMed

  81. Kreitman M. Assessment of variability within electromorphs of alcohol dehydrogenase in Drosophila melanogaster. Genetics. 1980 Jun; 95(2):467-75. View in: PubMed

  82. Kreitman M. Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature. 1983 Aug 4-10; 304(5925):412-7. View in: PubMed

  83. Hudson RR, Kreitman M, Aguadé M. A test of neutral molecular evolution based on nucleotide data. Genetics. 1987 May; 116(1):153-9. View in: PubMed

  84. Keith TP, Riley MA, Kreitman M, Lewontin RC, Curtis D, Chambers G. Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster. Genetics. 1987 May; 116(1):67-73. View in: PubMed

  85. Kreitman ME, Aguadé M. Excess polymorphism at the Adh locus in Drosophila melanogaster. Genetics. 1986 Sep; 114(1):93-110. View in: PubMed

  86. Kreitman M, Aguadé M. Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hybridization of four-nucleotide-recognizing restriction enzyme digests. Proc Natl Acad Sci U S A. 1986 May; 83(10):3562-6. View in: PubMed

  87. Kreitman M, Landweber LF. A strategy for producing single-stranded DNA in the polymerase chain reaction. A direct method for genomic sequencing. Gene Anal Tech. 1989 Jul-Aug; 6(4):84-8. View in: PubMed

  88. Wesley CS, Ben M, Kreitman M, Hagag N, Eanes WF. Cloning regions of the Drosophila genome by microdissection of polytene chromosome DNA and PCR with nonspecific primer. Nucleic Acids Res. 1990 Feb 11; 18(3):599-603. View in: PubMed

  89. McDonald JH, Kreitman M. Adaptive protein evolution at the Adh locus in Drosophila. Nature. 1991 Jun 20; 351(6328):652-4. View in: PubMed

  90. Berry AJ, Ajioka JW, Kreitman M. Lack of polymorphism on the Drosophila fourth chromosome resulting from selection. Genetics. 1991 Dec; 129(4):1111-7. View in: PubMed

  91. Kreitman M, Hudson RR. Inferring the evolutionary histories of the Adh and Adh-dup loci in Drosophila melanogaster from patterns of polymorphism and divergence. Genetics. 1991 Mar; 127(3):565-82. View in: PubMed

  92. Williams WV, Callegari P, Freundlich B, Keenan G, Eldridge D, Shin H, Kreitman M, McCallus D, Weiner DB. Molecular diagnosis of Borrelia burgdorferi infection (Lyme disease). DNA Cell Biol. 1992 Apr; 11(3):207-13. View in: PubMed