Chuan He, PhD

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

Harvard
Cambridge
Postdoc - Chemical Biology
2002

MIT
Cambridge
Ph.D. - Chemistry
2000

University of Sci. & Tech. China
Hefei/China
B.S. - Chemistry
1994

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency.
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency. Sci Adv. 2024 Oct 18; 10(42):eadp7727.
PMID: 39413186

5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. JCO Precis Oncol. 2024 Oct; 8:e2400277.
PMID: 39393034

RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis.
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature. 2024 Oct; 634(8035):986-994.
PMID: 39358506

Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance.
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance. Clin Cancer Res. 2024 Oct 01; 30(19):4450-4463.
PMID: 38691100

YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. J Clin Invest. 2024 Sep 26.
PMID: 39325547

IGF2BP3 promotes mRNA degradation through internal m7G modification.
IGF2BP3 promotes mRNA degradation through internal m7G modification. Nat Commun. 2024 Aug 28; 15(1):7421.
PMID: 39198433

RNA interacts with topoisomerase I to adjust DNA topology.
RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Sep 05; 84(17):3192-3208.e11.
PMID: 39173639

PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression.
PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression. Nat Commun. 2024 Aug 13; 15(1):6947.
PMID: 39138174

Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq.
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq. Nat Commun. 2024 Aug 10; 15(1):6852.
PMID: 39127768

YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges.
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges. bioRxiv. 2024 Aug 09.
PMID: 39149343

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ACS Chemical Biology Lectureship
2019

Paul Marks Prize in Cancer Research
2017

HHMI Investigator
2013