Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
Harvard
Cambridge
Postdoc - Chemical Biology
2002
MIT
Cambridge
Ph.D. - Chemistry
2000
University of Sci. & Tech. China
Hefei/China
B.S. - Chemistry
1994
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. Protein Cell. 2023 Sep 14; 14(9):683-697.
PMID: 37030005
6mA-METL-9 axis regulates innate immunity in C. elegans.
6mA-METL-9 axis regulates innate immunity in C. elegans. Cell Res. 2023 08; 33(8):581-582.
PMID: 37337028
YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs.
YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs. EMBO J. 2023 08 01; 42(15):e113126.
PMID: 37345898
Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling. Nat Protoc. 2023 Jun 22.
PMID: 37349502
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation. Cell Res. 2023 09; 33(9):727-730.
PMID: 37316584
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines. Database (Oxford). 2023 06 10; 2023.
PMID: 37387524
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines. Database (Oxford). 2023 06 10; 2023.
PMID: 37387525
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Cancer Cell. 2023 07 10; 41(7):1294-1308.e8.
PMID: 37236197
Advances in targeting RNA modifications for anticancer therapy.
Advances in targeting RNA modifications for anticancer therapy. Trends Cancer. 2023 07; 9(7):528-542.
PMID: 37147166
Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation. Mol Cell. 2023 04 06; 83(7):1022-1023.
PMID: 37028412
ACS Chemical Biology Lectureship
2019
Paul Marks Prize in Cancer Research
2017
HHMI Investigator
2013