Chuan He

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

Harvard
Cambridge
Postdoc - Chemical Biology
2002

MIT
Cambridge
Ph.D. - Chemistry
2000

University of Sci. & Tech. China
Hefei/China
B.S. - Chemistry
1994

Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling. Nat Protoc. 2023 Nov; 18(11):3652.
PMID: 37349502

Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research. Epigenetics. 2023 12; 18(1):2271692.
PMID: 37898998

Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma. Pediatr Blood Cancer. 2023 Oct 20; e30735.
PMID: 37859597

METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. Protein Cell. 2023 09 14; 14(9):683-697.
PMID: 37030005

KAS-Analyzer: a novel computational framework for exploring KAS-seq data.
KAS-Analyzer: a novel computational framework for exploring KAS-seq data. Bioinform Adv. 2023; 3(1):vbad121.
PMID: 37745002

Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA.
Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA. Methods Enzymol. 2023; 692:39-54.
PMID: 37925186

RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nat Cell Biol. 2023 09; 25(9):1359-1368.
PMID: 37640841

6mA-METL-9 axis regulates innate immunity in C. elegans.
6mA-METL-9 axis regulates innate immunity in C. elegans. Cell Res. 2023 08; 33(8):581-582.
PMID: 37337028

YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs.
YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs. EMBO J. 2023 08 01; 42(15):e113126.
PMID: 37345898

Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation. Cell Res. 2023 09; 33(9):727-730.
PMID: 37316584

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ACS Chemical Biology Lectureship
2019

Paul Marks Prize in Cancer Research
2017

HHMI Investigator
2013