My lab works on a wide variety of problems at the interface of Statistics and Genetics. We often tackle problems where novel statistical methods are required, or can learn something new compared with existing approaches. Thus, much of our research involves developing new statistical methodology, many of which have a non-trivial computational component. People in my lab tend to come from a quantitative background (e.g., Statistics, Computer Science), with varying levels of formal or informal Biology training.
fSuSiE enables fine-mapping of QTLs from genome-scale molecular profiles.
fSuSiE enables fine-mapping of QTLs from genome-scale molecular profiles. bioRxiv. 2025 Aug 17.
PMID: 40832254
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children. Am J Hum Genet. 2025 Jul 03; 112(7):1610-1624.
PMID: 40614707
BAYESIAN VARIABLE SELECTION IN A COX PROPORTIONAL HAZARDS MODEL WITH THE "SUM OF SINGLE EFFECTS" PRIOR.
BAYESIAN VARIABLE SELECTION IN A COX PROPORTIONAL HAZARDS MODEL WITH THE "SUM OF SINGLE EFFECTS" PRIOR. ArXiv. 2025 Jun 06.
PMID: 40503016
Disease-associated loci share properties with response eQTLs under common environmental exposures.
Disease-associated loci share properties with response eQTLs under common environmental exposures. Res Sq. 2025 May 14.
PMID: 40470191
Disease-associated loci share properties with response eQTLs under common environmental exposures.
Disease-associated loci share properties with response eQTLs under common environmental exposures. bioRxiv. 2025 May 04.
PMID: 40654932
Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects.
Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects. Am J Physiol Gastrointest Liver Physiol. 2025 Jun 01; 328(6):G696-G715.
PMID: 40257386
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition.
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition. Nat Genet. 2025 Jan; 57(1):263-273.
PMID: 39747597
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children. medRxiv. 2024 Oct 04.
PMID: 40034775
Accelerated dimensionality reduction of single-cell RNA sequencing data with fastglmpca.
Accelerated dimensionality reduction of single-cell RNA sequencing data with fastglmpca. Bioinformatics. 2024 08 02; 40(8).
PMID: 39110511
Accelerated dimensionality reduction of single-cell RNA sequencing data with fastglmpca.
Accelerated dimensionality reduction of single-cell RNA sequencing data with fastglmpca. bioRxiv. 2024 Jul 04.
PMID: 38585920