Improvements in the cost and speed of DNA sequencing and synthesis over the past two decades have made the dream of a technological world powered by the information storage and processing capacities of life’s molecular constituents increasingly realizable. Our lab develops technologies that apply both these advances and others in physics and computation to pressing problems in biology and medicine.
Refining the lens of DNA microscopy.
Refining the lens of DNA microscopy. Nat Comput Sci. 2024 Feb; 4(2):94-95.
PMID: 38365998
Volumetric imaging of an intact organism by a distributed molecular network.
Volumetric imaging of an intact organism by a distributed molecular network. bioRxiv. 2023 Aug 14.
PMID: 37645933
DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction.
DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction. Cell. 2019 06 27; 178(1):229-241.e16.
PMID: 31230717
Genetic measurement of memory B-cell recall using antibody repertoire sequencing.
Genetic measurement of memory B-cell recall using antibody repertoire sequencing. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13463-8.
PMID: 23898164
DNA targeting specificity of RNA-guided Cas9 nucleases.
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol. 2013 Sep; 31(9):827-32.
PMID: 23873081
Correlation of gene expression and genome mutation in single B-cells.
Correlation of gene expression and genome mutation in single B-cells. PLoS One. 2013; 8(6):e67624.
PMID: 23840752
Lineage structure of the human antibody repertoire in response to influenza vaccination.
Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013 Feb 06; 5(171):171ra19.
PMID: 23390249
Determinism and stochasticity during maturation of the zebrafish antibody repertoire.
Determinism and stochasticity during maturation of the zebrafish antibody repertoire. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5348-53.
PMID: 21393572
High-throughput sequencing of the zebrafish antibody repertoire.
High-throughput sequencing of the zebrafish antibody repertoire. Science. 2009 May 08; 324(5928):807-10.
PMID: 19423829