Joshua Weinstein

Assistant Professor
Websites
Research Summary
Improvements in the cost and speed of DNA sequencing and synthesis over the past two decades have made the dream of a technological world powered by the information storage and processing capacities of life’s molecular constituents increasingly realizable. Our lab develops technologies that apply both these advances and others in physics and computation to pressing problems in biology and medicine.
Publications
  1. Weinstein JA, Regev A, Zhang F. DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction. Cell. 2019 06 27; 178(1):229-241.e16. View in: PubMed

  2. Vollmers C, Sit RV, Weinstein JA, Dekker CL, Quake SR. Genetic measurement of memory B-cell recall using antibody repertoire sequencing. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13463-8. View in: PubMed

  3. Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol. 2013 Sep; 31(9):827-32. View in: PubMed

  4. Weinstein JA, Zeng X, Chien YH, Quake SR. Correlation of gene expression and genome mutation in single B-cells. PLoS One. 2013; 8(6):e67624. View in: PubMed

  5. Jiang N, He J, Weinstein JA, Penland L, Sasaki S, He XS, Dekker CL, Zheng NY, Huang M, Sullivan M, Wilson PC, Greenberg HB, Davis MM, Fisher DS, Quake SR. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013 Feb 06; 5(171):171ra19. View in: PubMed

  6. Jiang N, Weinstein JA, Penland L, White RA, Fisher DS, Quake SR. Determinism and stochasticity during maturation of the zebrafish antibody repertoire. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5348-53. View in: PubMed

  7. Weinstein JA, Jiang N, White RA, Fisher DS, Quake SR. High-throughput sequencing of the zebrafish antibody repertoire. Science. 2009 May 08; 324(5928):807-10. View in: PubMed