Joshua Weinstein | Committee on Genetics, Genomics and Systems Biology

Research Summary

Improvements in the cost and speed of DNA sequencing and synthesis over the past two decades have made the dream of a technological world powered by the information storage and processing capacities of life’s molecular constituents increasingly realizable. Our lab develops technologies that apply both these advances and others in physics and computation to pressing problems in biology and medicine.

Publications

DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction. Cell. 2019 06 27; 178(1):229-241.e16. View in: PubMed
Genetic measurement of memory B-cell recall using antibody repertoire sequencing. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13463-8. View in: PubMed
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol. 2013 Sep; 31(9):827-32. View in: PubMed
Correlation of gene expression and genome mutation in single B-cells. PLoS One. 2013; 8(6):e67624. View in: PubMed
Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013 Feb 06; 5(171):171ra19. View in: PubMed
Determinism and stochasticity during maturation of the zebrafish antibody repertoire. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5348-53. View in: PubMed
High-throughput sequencing of the zebrafish antibody repertoire. Science. 2009 May 08; 324(5928):807-10. View in: PubMed