Our group is interested in understanding how the architecture of the genome contributes to the specificity and robustness of the gene expression programs that govern embryonic development and cell differentiation.
Vertebrate genomes contain hundreds of thousands of regulatory sequences that can influence the expression of genes sometimes located hundreds of kilobases away. Our main goal is to understand how the folding of the genome in specific domains and dynamic structures contributes to transform such a dispersed information into highly specific regulatory ensembles. We study as well how perturbations of these processes, notably due to chromosomal rearrangements, could lead to developmental or oncogenic pathologies, but may have also participated to animal evolution.
University of Geneva
Geneva - Switzerland
- Developmental Genetics
2006
Université Pierre et Marie Curie - Paris 6
Paris - France
PhD - Cellular and Molecular Genetics
1997
Université Pierre et Marie Curie - Paris 6
Paris - France
DEA - Cellular and Molecular Genetics
1993
HYENA detects oncogenes activated by distal enhancers in cancer.
HYENA detects oncogenes activated by distal enhancers in cancer. Nucleic Acids Res. 2024 Sep 09; 52(16):e77.
PMID: 39051548
Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression.
Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression. Nat Commun. 2024 May 10; 15(1):3931.
PMID: 38729993
HYENA detects oncogenes activated by distal enhancers in cancer.
HYENA detects oncogenes activated by distal enhancers in cancer. bioRxiv. 2024 Apr 12.
PMID: 38076958
HYENA detects oncogenes activated by distal enhancers in cancer.
HYENA detects oncogenes activated by distal enhancers in cancer. bioRxiv. 2023 Nov 28.
PMID: 38076958
Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.
Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020 11; 18(11):e3000902.
PMID: 33201874
Chromosomes come together to help mice distinguish odours.
Chromosomes come together to help mice distinguish odours. Nature. 2019 01; 565(7740):439-440.
PMID: 30666054
Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature. 2018 06; 558(7711):E4.
PMID: 29769714
Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq.
Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq. Cell. 2018 05 31; 173(6):1520-1534.e20.
PMID: 29856957
Thromboprophylaxis in Spinal Surgery.
Mosenthal WP, Landy DC, Boyajian HH, Idowu OA, Shi LL, Ramos E, Lee MJ. Thromboprophylaxis in Spinal Surgery. Spine (Phila Pa 1976). 2018 04 15; 43(8):E474-E481.
PMID: 27867070
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature. 2018 01 25; 553(7689):515-520.
PMID: 29342133
elected member
European Molecular Biology Organisation
2016