Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529.
PMID: 37322120
DNA methylation-environment interactions in the human genome.
DNA methylation-environment interactions in the human genome. bioRxiv. 2023 May 19.
PMID: 37293015
Universal gut microbial relationships in the gut microbiome of wild baboons.
Universal gut microbial relationships in the gut microbiome of wild baboons. Elife. 2023 05 09; 12.
PMID: 37158607
[The Black Death, natural selection and susceptibility to auto-immune disorders].
[The Black Death, natural selection and susceptibility to auto-immune disorders]. Med Sci (Paris). 2023 04; 39(4):331-333.
PMID: 37094265
Genome graphs detect human polymorphisms in active epigenomic state during influenza infection.
Genome graphs detect human polymorphisms in active epigenomic state during influenza infection. Cell Genom. 2023 May 10; 3(5):100294.
PMID: 37228750
Reply to Barton et al: signatures of natural selection during the Black Death.
Reply to Barton et al: signatures of natural selection during the Black Death. bioRxiv. 2023 Apr 07.
PMID: 37066254
Transposable elements are associated with the variable response to influenza infection.
Transposable elements are associated with the variable response to influenza infection. Cell Genom. 2023 May 10; 3(5):100292.
PMID: 37228757
Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity.
Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity. Front Immunol. 2023; 14:1129577.
PMID: 36999024
Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection.
Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Front Immunol. 2022; 13:1044592.
PMID: 36776396
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.
PMID: 36630917