Luis Barreiro

Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.

University of Chicago
Chicago
Post-doc - Functional Genomics
2011

University of Paris VII
Paris
PhD - Population Genetics
2008

Lusófona University
Lisbon
Master - Biotechnological Engineering
2003

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177.
PMID: 38755196

A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection. PLoS Biol. 2024 Apr; 22(4):e3002259.
PMID: 38683873

Shaping immunity: The influence of natural selection on population immune diversity.
Shaping immunity: The influence of natural selection on population immune diversity. Immunol Rev. 2024 May; 323(1):227-240.
PMID: 38577999

Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Jun; 267:106851.
PMID: 38479480

EpiVar Browser: advanced exploration of epigenomics data under controlled access.
EpiVar Browser: advanced exploration of epigenomics data under controlled access. Bioinformatics. 2024 Mar 04; 40(3).
PMID: 38449289

Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet. 2024 Mar; 56(3):408-419.
PMID: 38424460

DNA methylation-environment interactions in the human genome.
DNA methylation-environment interactions in the human genome. Elife. 2024 Feb 26; 12.
PMID: 38407202

Microbial transmission in the social microbiome and host health and disease.
Microbial transmission in the social microbiome and host health and disease. Cell. 2024 01 04; 187(1):17-43.
PMID: 38181740

The evolutionary tale of lactase persistence in humans.
The evolutionary tale of lactase persistence in humans. Nat Rev Genet. 2024 Jan; 25(1):7.
PMID: 37749209

Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue.
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue. Cell Rep. 2024 01 23; 43(1):113616.
PMID: 38150367

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