The McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities. We focus on myeloid malignancies which are particularly difficult to treat. We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome. Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling. Please visit our webpage for more information https://voices.uchicago.edu/mcnerneylab/
The University of Chicago
Chicago
Postdoctoral - Genomics and Systems Biology
2014The University of Chicago
Chicago
Residency - Clinical Pathology
2010The University of Chicago
Chicago
MD - Medicine
2007The University of Chicago
Chicago
PhD - Immunology
2005Northwestern University
Evanston
B.A. - Molecular and Cellular Biology
1999YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. J Clin Invest. 2024 Dec 02; 134(23).
PMID: 39325547Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms.
Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms. Blood Cancer J. 2024 06 18; 14(1):99.
PMID: 38890297CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex.
CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex. Cell Rep. 2024 May 28; 43(5):114227.
PMID: 38735044Haploinsufficient Transcription Factors in Myeloid Neoplasms.
Haploinsufficient Transcription Factors in Myeloid Neoplasms. Annu Rev Pathol. 2024 Jan 24; 19:571-598.
PMID: 37906947Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells. Oncogene. 2023 03; 42(12):881-893.
PMID: 36725889Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms. Br J Haematol. 2023 02; 200(4):489-493.
PMID: 36349721EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy.
EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy. Exp Hematol. 2022 11; 115:54-67.
PMID: 35995095The significance of CUX1 and chromosome 7 in myeloid malignancies.
The significance of CUX1 and chromosome 7 in myeloid malignancies. Curr Opin Hematol. 2022 03 01; 29(2):92-102.
PMID: 35084368CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions.
CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. Leukemia. 2022 05; 36(5):1421-1425.
PMID: 35034954Genomic studies controvert the existence of the CUX1 p75 isoform.
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Genomic studies controvert the existence of the CUX1 p75 isoform. Sci Rep. 2022 01 07; 12(1):151.
PMID: 34997000Leukemia and Lymphoma Society Scholar Award
2022Faculty Award for Excellence in Graduate Teaching and Mentoring
2020American Cancer Society Research Scholar Award
2019American Society of Hematology Junior Faculty Scholar Award
2017Nachman Fellow, Dept. of Pediatrics Hematology-Oncology
2015“V” Foundation in Cancer Research Scholar Award
2014Leukemia and Lymphoma Society, Illinois Chapter Researcher of the Year
2013Evans Travel Award, FASEB Hematologic Malignancies Science Research Conference
2013Cancer Research Foundation Young Investigator Award
2013Leukemia and Lymphoma Society Fellow Award
2011Robert W. Wissler Fellowship Award, Department of Pathology
2010Resident Research Grant, College of American Pathologists
2009Leon Jacobson Prize for Senior Scientific Presentation, Pritzker School of Medicine
2007Honorable Mention Best PhD Dissertation Award, Biological Sciences, University of Chicago
2006Committee on Immunology Best PhD Thesis Award, University of Chicago
2006Robert E. Priest Pathology Merit Award, Department of Pathology, University of Chicago
2005Doolittle-Harrison Travel Fellowship, University of Chicago
2004Elaine Frank Family Fellowship for Medical Research, MSTP, University of Chicago
2003Medical Scientist Training Program, NIH
2000 - 2007Graduation with Departmental Honors, Biological Sciences, Northwestern University
1999Graduation Cum Laude, Northwestern University
1999Edgar Macey Scholarship for Summer Research, Northwestern University
1997