We develop quantitative and computational methods and tools to sift through the vast amounts of genomic and other high dimensional data with the goal of making discoveries that can be translated to improve human health.
University of Chicago
Chicago
PhD - Statistics
2005Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits.
Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits. Genome Biol. 2025 Feb 03; 26(1):19.
PMID: 39901160Pervasive polygenicity of complex traits inflates false positive rates in transcriptome-wide association studies.
Pervasive polygenicity of complex traits inflates false positive rates in transcriptome-wide association studies. bioRxiv. 2024 Nov 15.
PMID: 37904952scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type-specific transcriptome-wide association study framework.
scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type-specific transcriptome-wide association study framework. bioRxiv. 2024 Nov 14.
PMID: 39605417A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer.
A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer. Am J Hum Genet. 2024 06 06; 111(6):1100-1113.
PMID: 38733992Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. Am J Hum Genet. 2024 03 07; 111(3):445-455.
PMID: 38320554On the problem of inflation in transcriptome-wide association studies.
On the problem of inflation in transcriptome-wide association studies. bioRxiv. 2023 Oct 20.
PMID: 37904952Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.
Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility. Cancer Epidemiol Biomarkers Prev. 2023 09 01; 32(9):1198-1207.
PMID: 37409955Revealing polygenic pleiotropy using genetic risk scores for asthma.
Revealing polygenic pleiotropy using genetic risk scores for asthma. HGG Adv. 2023 10 12; 4(4):100233.
PMID: 37663543Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.
Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations. HGG Adv. 2023 Oct 12; 4(4):100216.
PMID: 37869564Predicting molecular mechanisms of hereditary diseases by using their tissue-selective manifestation.
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Predicting molecular mechanisms of hereditary diseases by using their tissue-selective manifestation. Mol Syst Biol. 2023 08 08; 19(8):e11407.
PMID: 37232043