Software identified the METTL3 gene (left) as a potential "driver gene" for bladder cancer. The closeups below show areas with genetic mutations.
Identifying which gene mutations are most likely to propel cancer forward can help doctors treat cancer patients more effectively and help researchers better understand the biology of cancer. But finding these “driver” genes isn’t easy. Any cell can and will acquire gene mutations, but only a fraction of those aberrations have the potential to survive, proliferate and create tumors.
Surface view of a Drosophila egg chamber, the multicellular precursor to the egg. The follicular epithelial cells that form the egg chamber’s outer layer collectively migrate along the extracellular matrix (ECM) that surrounds the organ. This collective migration, in turn, causes the entire egg chamber to rotate within the ECM to create the elongated shape of the egg.
Sally Horne-Badovinac, PhD, was studying zebrafish to gain insight into how human intestines develop when she had ascientific epiphany. While staring through a high-powered microscope at a section of the fish’s gut tube—their version of intestines—she happened to glance at some neighboring tissue.
One of the most important questions in biology is how rapidly new proteins evolve in organisms. Proteins are the building blocks that carry out the basic functions of life. As the genes that produce them change, the proteins change as well, introducing new functionality or traits that can eventually lead to the evolution of new species.
Four University of Chicago faculty members have earned prestigious Sloan Research Fellowships, awarded to early-career scholars whose achievements and potential mark them as the next scientific leaders.
The American Cancer Society has named Michelle M. Le Beau, PhD, director of the University of Chicago Medicine Comprehensive Cancer Center, to its board of directors, with a term beginning on Jan. 1, 2019.
Congratulations John Blischak (GGSB Alum) - 2018 winner of the "Nan Xiao prize for computational reproducibility" for his leadership role in computational reproducibility in applications, and especially development of the R package workflow.
Thanks to a generous gift from Human Genetics Alum Nan Xiao, the Department of Human Genetics is pleased to announce the establishment of the "Nan Xiao prize for computational reproducibility".
Duplicate copies of a gene shared by male and female fruit flies have evolved to resolve competing demands between the sexes. New genetic analysis by researchers at the University of Chicago describes how these copies have evolved separate male- and female-specific functions that are crucial to reproduction and fertility.
For the first time, DNA contributed by Sub-Saharan African women has been thoroughly evaluated with innovative genomics technology in an effort to understand the genetic bases for breast cancer in African populations.