Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011University of Paris VII
Paris
PhD - Population Genetics
2008Lusófona University
Lisbon
Master - Biotechnological Engineering
2003Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation.
Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation. Mol Med. 2024 Dec 28; 30(1):280.
PMID: 39730996Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts.
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts. medRxiv. 2024 Dec 12.
PMID: 39711700Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients. bioRxiv. 2024 Dec 04.
PMID: 39677792BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses.
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses. Immunity. 2024 Sep 10; 57(9):2095-2107.e8.
PMID: 39153479A female-biased gene expression signature of dominance in cooperatively breeding meerkats.
A female-biased gene expression signature of dominance in cooperatively breeding meerkats. Mol Ecol. 2024 Nov; 33(21):e17467.
PMID: 39021304High-throughput screen identifies non inflammatory small molecule inducers of trained immunity.
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2400413121.
PMID: 38976741Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177.
PMID: 38755196A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection. PLoS Biol. 2024 Apr; 22(4):e3002259.
PMID: 38683873Shaping immunity: The influence of natural selection on population immune diversity.
Shaping immunity: The influence of natural selection on population immune diversity. Immunol Rev. 2024 May; 323(1):227-240.
PMID: 38577999Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.
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Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Jun; 267:106851.
PMID: 38479480